Two-Stage Capture Employing Active Transport Enables Sensitive and Fast Biosensors

[Image: see text] Nanoscale sensors enable the detection of analytes with improved signal-to-noise ratio but suffer from mass transport limitations. Molecular shuttles, assembled from, e.g., antibody-functionalized microtubules and kinesin motor proteins, can selectively capture analytes from soluti...

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Detalles Bibliográficos
Autores principales: Katira, Parag, Hess, Henry
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2010
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819759/
https://www.ncbi.nlm.nih.gov/pubmed/20055432
http://dx.doi.org/10.1021/nl903468p
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author Katira, Parag
Hess, Henry
author_facet Katira, Parag
Hess, Henry
author_sort Katira, Parag
collection PubMed
description [Image: see text] Nanoscale sensors enable the detection of analytes with improved signal-to-noise ratio but suffer from mass transport limitations. Molecular shuttles, assembled from, e.g., antibody-functionalized microtubules and kinesin motor proteins, can selectively capture analytes from solution and deliver the analytes to a sensor patch. This two-stage process can accelerate mass transport to nanoscale biosensors and facilitate the rapid detection of analytes. Here, the possible increase of the signal-to-noise ratio is calculated, and the optimal layout of a system which integrates active transport is determined.
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spelling pubmed-28197592010-02-10 Two-Stage Capture Employing Active Transport Enables Sensitive and Fast Biosensors Katira, Parag Hess, Henry Nano Lett [Image: see text] Nanoscale sensors enable the detection of analytes with improved signal-to-noise ratio but suffer from mass transport limitations. Molecular shuttles, assembled from, e.g., antibody-functionalized microtubules and kinesin motor proteins, can selectively capture analytes from solution and deliver the analytes to a sensor patch. This two-stage process can accelerate mass transport to nanoscale biosensors and facilitate the rapid detection of analytes. Here, the possible increase of the signal-to-noise ratio is calculated, and the optimal layout of a system which integrates active transport is determined. American Chemical Society 2010-01-07 2010-02-10 /pmc/articles/PMC2819759/ /pubmed/20055432 http://dx.doi.org/10.1021/nl903468p Text en Copyright © 2010 American Chemical Society http://pubs.acs.org This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org.
spellingShingle Katira, Parag
Hess, Henry
Two-Stage Capture Employing Active Transport Enables Sensitive and Fast Biosensors
title Two-Stage Capture Employing Active Transport Enables Sensitive and Fast Biosensors
title_full Two-Stage Capture Employing Active Transport Enables Sensitive and Fast Biosensors
title_fullStr Two-Stage Capture Employing Active Transport Enables Sensitive and Fast Biosensors
title_full_unstemmed Two-Stage Capture Employing Active Transport Enables Sensitive and Fast Biosensors
title_short Two-Stage Capture Employing Active Transport Enables Sensitive and Fast Biosensors
title_sort two-stage capture employing active transport enables sensitive and fast biosensors
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819759/
https://www.ncbi.nlm.nih.gov/pubmed/20055432
http://dx.doi.org/10.1021/nl903468p
work_keys_str_mv AT katiraparag twostagecaptureemployingactivetransportenablessensitiveandfastbiosensors
AT hesshenry twostagecaptureemployingactivetransportenablessensitiveandfastbiosensors

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