Cargando…

Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007

Foot-and-mouth disease (FMD) is endemic to sub-Saharan Africa. To further understand its complex epidemiology, which involves multiple virus serotypes and host species, we characterized the viruses recovered from FMD outbreaks in Ethiopia during 1981–2007. We detected 5 of the 7 FMDV serotypes (O, A...

Descripción completa

Detalles Bibliográficos
Autores principales: Ayelet, Gelagay, Mahapatra, Mana, Gelaye, Esayas, Egziabher, Berhe G., Rufeal, Tesfaye, Sahle, Mesfin, Ferris, Nigel P., Wadsworth, Jemma, Hutchings, Geoffrey H., Knowles, Nick J.
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819860/
https://www.ncbi.nlm.nih.gov/pubmed/19788808
http://dx.doi.org/10.3201/eid1509.090091
_version_ 1782177318610927616
author Ayelet, Gelagay
Mahapatra, Mana
Gelaye, Esayas
Egziabher, Berhe G.
Rufeal, Tesfaye
Sahle, Mesfin
Ferris, Nigel P.
Wadsworth, Jemma
Hutchings, Geoffrey H.
Knowles, Nick J.
author_facet Ayelet, Gelagay
Mahapatra, Mana
Gelaye, Esayas
Egziabher, Berhe G.
Rufeal, Tesfaye
Sahle, Mesfin
Ferris, Nigel P.
Wadsworth, Jemma
Hutchings, Geoffrey H.
Knowles, Nick J.
author_sort Ayelet, Gelagay
collection PubMed
description Foot-and-mouth disease (FMD) is endemic to sub-Saharan Africa. To further understand its complex epidemiology, which involves multiple virus serotypes and host species, we characterized the viruses recovered from FMD outbreaks in Ethiopia during 1981–2007. We detected 5 of the 7 FMDV serotypes (O, A, C, Southern African Territories [SAT] 1, and SAT 2). Serotype O predominated, followed by serotype A; type C was not recognized after 1983. Phylogenetic analysis of virus protein 1 sequences indicated emergence of a new topotype within serotype O, East Africa 4. In 2007, serotype SAT 1 was detected in Ethiopia and formed a new distinct topotype (IX), and serotype SAT 2 reappeared after an apparent gap of 16 years. The diversity of viruses highlights the role of this region as a reservoir for FMD virus, and their continuing emergence in Ethiopia will greatly affect spread and consequent control strategy of the disease on this continent.
format Text
id pubmed-2819860
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Centers for Disease Control and Prevention
record_format MEDLINE/PubMed
spelling pubmed-28198602010-02-23 Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007 Ayelet, Gelagay Mahapatra, Mana Gelaye, Esayas Egziabher, Berhe G. Rufeal, Tesfaye Sahle, Mesfin Ferris, Nigel P. Wadsworth, Jemma Hutchings, Geoffrey H. Knowles, Nick J. Emerg Infect Dis Research Foot-and-mouth disease (FMD) is endemic to sub-Saharan Africa. To further understand its complex epidemiology, which involves multiple virus serotypes and host species, we characterized the viruses recovered from FMD outbreaks in Ethiopia during 1981–2007. We detected 5 of the 7 FMDV serotypes (O, A, C, Southern African Territories [SAT] 1, and SAT 2). Serotype O predominated, followed by serotype A; type C was not recognized after 1983. Phylogenetic analysis of virus protein 1 sequences indicated emergence of a new topotype within serotype O, East Africa 4. In 2007, serotype SAT 1 was detected in Ethiopia and formed a new distinct topotype (IX), and serotype SAT 2 reappeared after an apparent gap of 16 years. The diversity of viruses highlights the role of this region as a reservoir for FMD virus, and their continuing emergence in Ethiopia will greatly affect spread and consequent control strategy of the disease on this continent. Centers for Disease Control and Prevention 2009-09 /pmc/articles/PMC2819860/ /pubmed/19788808 http://dx.doi.org/10.3201/eid1509.090091 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Ayelet, Gelagay
Mahapatra, Mana
Gelaye, Esayas
Egziabher, Berhe G.
Rufeal, Tesfaye
Sahle, Mesfin
Ferris, Nigel P.
Wadsworth, Jemma
Hutchings, Geoffrey H.
Knowles, Nick J.
Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007
title Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007
title_full Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007
title_fullStr Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007
title_full_unstemmed Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007
title_short Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007
title_sort genetic characterization of foot-and-mouth disease viruses, ethiopia, 1981–2007
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819860/
https://www.ncbi.nlm.nih.gov/pubmed/19788808
http://dx.doi.org/10.3201/eid1509.090091
work_keys_str_mv AT ayeletgelagay geneticcharacterizationoffootandmouthdiseasevirusesethiopia19812007
AT mahapatramana geneticcharacterizationoffootandmouthdiseasevirusesethiopia19812007
AT gelayeesayas geneticcharacterizationoffootandmouthdiseasevirusesethiopia19812007
AT egziabherberheg geneticcharacterizationoffootandmouthdiseasevirusesethiopia19812007
AT rufealtesfaye geneticcharacterizationoffootandmouthdiseasevirusesethiopia19812007
AT sahlemesfin geneticcharacterizationoffootandmouthdiseasevirusesethiopia19812007
AT ferrisnigelp geneticcharacterizationoffootandmouthdiseasevirusesethiopia19812007
AT wadsworthjemma geneticcharacterizationoffootandmouthdiseasevirusesethiopia19812007
AT hutchingsgeoffreyh geneticcharacterizationoffootandmouthdiseasevirusesethiopia19812007
AT knowlesnickj geneticcharacterizationoffootandmouthdiseasevirusesethiopia19812007