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Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007
Foot-and-mouth disease (FMD) is endemic to sub-Saharan Africa. To further understand its complex epidemiology, which involves multiple virus serotypes and host species, we characterized the viruses recovered from FMD outbreaks in Ethiopia during 1981–2007. We detected 5 of the 7 FMDV serotypes (O, A...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Centers for Disease Control and Prevention
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819860/ https://www.ncbi.nlm.nih.gov/pubmed/19788808 http://dx.doi.org/10.3201/eid1509.090091 |
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author | Ayelet, Gelagay Mahapatra, Mana Gelaye, Esayas Egziabher, Berhe G. Rufeal, Tesfaye Sahle, Mesfin Ferris, Nigel P. Wadsworth, Jemma Hutchings, Geoffrey H. Knowles, Nick J. |
author_facet | Ayelet, Gelagay Mahapatra, Mana Gelaye, Esayas Egziabher, Berhe G. Rufeal, Tesfaye Sahle, Mesfin Ferris, Nigel P. Wadsworth, Jemma Hutchings, Geoffrey H. Knowles, Nick J. |
author_sort | Ayelet, Gelagay |
collection | PubMed |
description | Foot-and-mouth disease (FMD) is endemic to sub-Saharan Africa. To further understand its complex epidemiology, which involves multiple virus serotypes and host species, we characterized the viruses recovered from FMD outbreaks in Ethiopia during 1981–2007. We detected 5 of the 7 FMDV serotypes (O, A, C, Southern African Territories [SAT] 1, and SAT 2). Serotype O predominated, followed by serotype A; type C was not recognized after 1983. Phylogenetic analysis of virus protein 1 sequences indicated emergence of a new topotype within serotype O, East Africa 4. In 2007, serotype SAT 1 was detected in Ethiopia and formed a new distinct topotype (IX), and serotype SAT 2 reappeared after an apparent gap of 16 years. The diversity of viruses highlights the role of this region as a reservoir for FMD virus, and their continuing emergence in Ethiopia will greatly affect spread and consequent control strategy of the disease on this continent. |
format | Text |
id | pubmed-2819860 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-28198602010-02-23 Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007 Ayelet, Gelagay Mahapatra, Mana Gelaye, Esayas Egziabher, Berhe G. Rufeal, Tesfaye Sahle, Mesfin Ferris, Nigel P. Wadsworth, Jemma Hutchings, Geoffrey H. Knowles, Nick J. Emerg Infect Dis Research Foot-and-mouth disease (FMD) is endemic to sub-Saharan Africa. To further understand its complex epidemiology, which involves multiple virus serotypes and host species, we characterized the viruses recovered from FMD outbreaks in Ethiopia during 1981–2007. We detected 5 of the 7 FMDV serotypes (O, A, C, Southern African Territories [SAT] 1, and SAT 2). Serotype O predominated, followed by serotype A; type C was not recognized after 1983. Phylogenetic analysis of virus protein 1 sequences indicated emergence of a new topotype within serotype O, East Africa 4. In 2007, serotype SAT 1 was detected in Ethiopia and formed a new distinct topotype (IX), and serotype SAT 2 reappeared after an apparent gap of 16 years. The diversity of viruses highlights the role of this region as a reservoir for FMD virus, and their continuing emergence in Ethiopia will greatly affect spread and consequent control strategy of the disease on this continent. Centers for Disease Control and Prevention 2009-09 /pmc/articles/PMC2819860/ /pubmed/19788808 http://dx.doi.org/10.3201/eid1509.090091 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Ayelet, Gelagay Mahapatra, Mana Gelaye, Esayas Egziabher, Berhe G. Rufeal, Tesfaye Sahle, Mesfin Ferris, Nigel P. Wadsworth, Jemma Hutchings, Geoffrey H. Knowles, Nick J. Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007 |
title | Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007 |
title_full | Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007 |
title_fullStr | Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007 |
title_full_unstemmed | Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007 |
title_short | Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007 |
title_sort | genetic characterization of foot-and-mouth disease viruses, ethiopia, 1981–2007 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819860/ https://www.ncbi.nlm.nih.gov/pubmed/19788808 http://dx.doi.org/10.3201/eid1509.090091 |
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