Nanoparticulate Quillaja saponin induces apoptosis in human leukemia cell lines with a high therapeutic index

Saponin fractions of Quillaja saponaria Molina (QS) have cytotoxic activity against cancer cells in vitro, but are too toxic to be useful in the clinic. The toxic effect was abolished by converting QS fractions into stable nanoparticles through the binding of QS to cholesterol. Two fractions of QS w...

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Detalles Bibliográficos
Autores principales: Hu, Kefei, Berenjian, Saideh, Larsson, Rolf, Gullbo, Joachim, Nygren, Peter, Lövgren, Tanja, Morein, Bror
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819906/
https://www.ncbi.nlm.nih.gov/pubmed/20161987

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