Down-regulation of Toll-like receptor 4 gene expression by short interfering RNA attenuates bone cancer pain in a rat model

BACKGROUND: This study demonstrates a critical role in CNS innate immunity of the microglial Toll-like receptor 4 (TLR4) in the induction and maintenance of behavioral hypersensitivity in a rat model of bone cancer pain with the technique of RNA interference (RNAi). We hypothesized that after intram...

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Detalles Bibliográficos
Autores principales: Lan, Liu Si, Ping, Yang Jian, Na, Wang Li, Miao, Jiang, Cheng, Qiu Qiao, Ni, Ma Zhen, Lei, Liu, Fang, Li Cai, Guang, Ren Chun, Jin, Zhou, Wei, Li
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819998/
https://www.ncbi.nlm.nih.gov/pubmed/20089147
http://dx.doi.org/10.1186/1744-8069-6-2

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