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Remembrance of Dead Cells Past: Discovering That the Extracellular Matrix Is a Cell Survival Factor
In 1992, Jere Meredith and I followed up on a serendipitous observation and showed that matrix deprivation can lead to apoptosis. Our article in Molecular Biology of the Cell, together with work form Steve Frisch's lab, helped establish the paradigm that integrin signals control cell survival i...
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Formato: | Texto |
Lenguaje: | English |
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The American Society for Cell Biology
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820415/ https://www.ncbi.nlm.nih.gov/pubmed/20150528 http://dx.doi.org/10.1091/mbc.E09-07-0602 |
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author | Schwartz, Martin A. |
author_facet | Schwartz, Martin A. |
author_sort | Schwartz, Martin A. |
collection | PubMed |
description | In 1992, Jere Meredith and I followed up on a serendipitous observation and showed that matrix deprivation can lead to apoptosis. Our article in Molecular Biology of the Cell, together with work form Steve Frisch's lab, helped establish the paradigm that integrin signals control cell survival in a variety of systems. It has been a pleasure to watch that work take on a life of its own as other investigators have explored its role in processes such as cavitation, regression of the mammary gland at the end of pregnancy, cancer metastasis, and tumor resistance to chemotherapy. Recently, we described an exception to the paradigm: In some tumors, reagents that activate integrin signaling enhance apoptosis in response to chemotherapy. |
format | Text |
id | pubmed-2820415 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | The American Society for Cell Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-28204152010-04-30 Remembrance of Dead Cells Past: Discovering That the Extracellular Matrix Is a Cell Survival Factor Schwartz, Martin A. Mol Biol Cell Retrospective In 1992, Jere Meredith and I followed up on a serendipitous observation and showed that matrix deprivation can lead to apoptosis. Our article in Molecular Biology of the Cell, together with work form Steve Frisch's lab, helped establish the paradigm that integrin signals control cell survival in a variety of systems. It has been a pleasure to watch that work take on a life of its own as other investigators have explored its role in processes such as cavitation, regression of the mammary gland at the end of pregnancy, cancer metastasis, and tumor resistance to chemotherapy. Recently, we described an exception to the paradigm: In some tumors, reagents that activate integrin signaling enhance apoptosis in response to chemotherapy. The American Society for Cell Biology 2010-02-15 /pmc/articles/PMC2820415/ /pubmed/20150528 http://dx.doi.org/10.1091/mbc.E09-07-0602 Text en © 2010 by The American Society for Cell Biology |
spellingShingle | Retrospective Schwartz, Martin A. Remembrance of Dead Cells Past: Discovering That the Extracellular Matrix Is a Cell Survival Factor |
title | Remembrance of Dead Cells Past: Discovering That the Extracellular Matrix Is a Cell Survival Factor |
title_full | Remembrance of Dead Cells Past: Discovering That the Extracellular Matrix Is a Cell Survival Factor |
title_fullStr | Remembrance of Dead Cells Past: Discovering That the Extracellular Matrix Is a Cell Survival Factor |
title_full_unstemmed | Remembrance of Dead Cells Past: Discovering That the Extracellular Matrix Is a Cell Survival Factor |
title_short | Remembrance of Dead Cells Past: Discovering That the Extracellular Matrix Is a Cell Survival Factor |
title_sort | remembrance of dead cells past: discovering that the extracellular matrix is a cell survival factor |
topic | Retrospective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820415/ https://www.ncbi.nlm.nih.gov/pubmed/20150528 http://dx.doi.org/10.1091/mbc.E09-07-0602 |
work_keys_str_mv | AT schwartzmartina remembranceofdeadcellspastdiscoveringthattheextracellularmatrixisacellsurvivalfactor |