High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation

BACKGROUND: Neurofibrillary tangles (NFT), a cardinal neuropathological feature of Alzheimer's disease (AD) that is highly correlated with synaptic loss and dementia severity, appear to be partly attributable to increased phosphorylation of the microtubule stabilizing protein tau at certain AD-...

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Detalles Bibliográficos
Autores principales: Azorsa, David O, Robeson, RiLee H, Frost, Danielle, hoovet, Bessie Meec, Brautigam, Gillian R, Dickey, Chad, Beaudry, Christian, Basu, Gargi D, Holz, David R, Hernandez, Joseph A, Bisanz, Kristen M, Gwinn, Leslie, Grover, Andrew, Rogers, Joseph, Reiman, Eric M, Hutton, Michael, Stephan, Dietrich A, Mousses, Spyro, Dunckley, Travis
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820455/
https://www.ncbi.nlm.nih.gov/pubmed/20067632
http://dx.doi.org/10.1186/1471-2164-11-25

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