Activity and Cellular Localization of an Oncogenic Glioblastoma Multiforme-associated EGF Receptor Mutant Possessing a Duplicated Kinase Domain

A mutation of the epidermal growth factor receptor (EGFR) that results in a tandem kinase domain duplication (TKD-EGFR) has been described in glioblastoma multiforme biopsies and cell lines. Although the TKD-EGFR confers tumorigenicity, little is known about the molecular underpinnings of receptor d...

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Detalles Bibliográficos
Autores principales: Ozer, Byram H., Wiepz, Gregory J., Bertics, Paul J.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820599/
https://www.ncbi.nlm.nih.gov/pubmed/19915609
http://dx.doi.org/10.1038/onc.2009.385

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