Copy number variant detection in inbred strains from short read sequence data

Summary: We have developed an algorithm to detect copy number variants (CNVs) in homozygous organisms, such as inbred laboratory strains of mice, from short read sequence data. Our novel approach exploits the fact that inbred mice are homozygous at virtually every position in the genome to detect CN...

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Detalles Bibliográficos
Autores principales: Simpson, Jared T., McIntyre, Rebecca E., Adams, David J., Durbin, Richard
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Applications Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820678/
https://www.ncbi.nlm.nih.gov/pubmed/20022973
http://dx.doi.org/10.1093/bioinformatics/btp693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820678/
https://www.ncbi.nlm.nih.gov/pubmed/20022973
http://dx.doi.org/10.1093/bioinformatics/btp693

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