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Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway

At clinically relevant doses, chemotherapeutic S(N)1 DNA methylating agents induce an ATR-mediated checkpoint response in human cells that is dependent on functional MutSα and MutLα. Deficiency of either mismatch repair activity renders cells highly resistant to this class of drug, but the mechanism...

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Detalles Bibliográficos
Autores principales:	Liu, Yiyong, Fang, Yanan, Shao, Hongbing, Lindsey-Boltz, Laura, Sancar, Aziz, Modrich, Paul
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	DNA and Chromosomes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820822/ https://www.ncbi.nlm.nih.gov/pubmed/20029092 http://dx.doi.org/10.1074/jbc.M109.076109

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