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Real-time in vivo imaging of p16(Ink4a )gene expression: a new approach to study senescence stress signaling in living animals
Oncogenic proliferative signals are coupled to a variety of growth inhibitory processes. In cultured primary human fibroblasts, for example, ectopic expression of oncogenic Ras or its downstream mediator initiates cellular senescence, the state of irreversible cell cycle arrest, through up-regulatio...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821322/ https://www.ncbi.nlm.nih.gov/pubmed/20157424 http://dx.doi.org/10.1186/1747-1028-5-1 |