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Real-time in vivo imaging of p16(Ink4a )gene expression: a new approach to study senescence stress signaling in living animals

Oncogenic proliferative signals are coupled to a variety of growth inhibitory processes. In cultured primary human fibroblasts, for example, ectopic expression of oncogenic Ras or its downstream mediator initiates cellular senescence, the state of irreversible cell cycle arrest, through up-regulatio...

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Detalles Bibliográficos
Autores principales: Ohtani, Naoko, Yamakoshi, Kimi, Takahashi, Akiko, Hara, Eiji
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821322/
https://www.ncbi.nlm.nih.gov/pubmed/20157424
http://dx.doi.org/10.1186/1747-1028-5-1

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