Back-translation for discovering distant protein homologies in the presence of frameshift mutations

BACKGROUND: Frameshift mutations in protein-coding DNA sequences produce a drastic change in the resulting protein sequence, which prevents classic protein alignment methods from revealing the proteins' common origin. Moreover, when a large number of substitutions are additionally involved in t...

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Detalles Bibliográficos
Autores principales: Gîrdea, Marta, Noé, Laurent, Kucherov, Gregory
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821327/
https://www.ncbi.nlm.nih.gov/pubmed/20047662
http://dx.doi.org/10.1186/1748-7188-5-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821327/
https://www.ncbi.nlm.nih.gov/pubmed/20047662
http://dx.doi.org/10.1186/1748-7188-5-6

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