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Back-translation for discovering distant protein homologies in the presence of frameshift mutations
BACKGROUND: Frameshift mutations in protein-coding DNA sequences produce a drastic change in the resulting protein sequence, which prevents classic protein alignment methods from revealing the proteins' common origin. Moreover, when a large number of substitutions are additionally involved in t...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821327/ https://www.ncbi.nlm.nih.gov/pubmed/20047662 http://dx.doi.org/10.1186/1748-7188-5-6 |