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A sticky situation: CCN1 promotes both proliferation and apoptosis of cancer cells
Members of the CCN family of matricellular signaling regulators promote cell adhesion through integrins and heparan sulfate-containing proteoglycans. A paradox of the CCN field is that, depending on the set of circumstances examined, individual CCN molecules can have quite different, and often oppos...
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821478/ https://www.ncbi.nlm.nih.gov/pubmed/19834822 http://dx.doi.org/10.1007/s12079-009-0079-x |
Sumario: | Members of the CCN family of matricellular signaling regulators promote cell adhesion through integrins and heparan sulfate-containing proteoglycans. A paradox of the CCN field is that, depending on the set of circumstances examined, individual CCN molecules can have quite different, and often opposing, effects. In a recent report, Franzen and colleagues (Mol Cancer Res. 7:1045–1055, 2009) show using siRNA knockdown that CCN1 (cyr61) is essential for the proliferation of prostate cancer cells. Intriguingly, on the other hand, CCN1 also enhances TRAIL-induced apoptosis. Thus the utility of anti-CCN1 therapy in cancer needs to be carefully considered in light of these divergent results. The significance of this paper is discussed. |
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