Getting to the heart of the matter: CCN2 plays a role in cardiomyocyte hypertrophy

Connective tissue growth factor (CTGF/CCN2) is overexpressed in diabetes. Diabetic rats possess myocardial and cardiomyocyte hypertrophy. In a recent report, Wang and colleagues (Am J Physiol Cell Physiol. 2009 Jul 22. [Epub ahead of print]) show that CCN2 directly mediates cardiomyocyte hypertrophy...

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Autor principal: Leask, Andrew
Formato: Texto
Lenguaje:English
Publicado: Springer Netherlands 2009
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821479/
https://www.ncbi.nlm.nih.gov/pubmed/19701807
http://dx.doi.org/10.1007/s12079-009-0061-7
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author Leask, Andrew
author_facet Leask, Andrew
author_sort Leask, Andrew
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description Connective tissue growth factor (CTGF/CCN2) is overexpressed in diabetes. Diabetic rats possess myocardial and cardiomyocyte hypertrophy. In a recent report, Wang and colleagues (Am J Physiol Cell Physiol. 2009 Jul 22. [Epub ahead of print]) show that CCN2 directly mediates cardiomyocyte hypertrophy as well as that induced by high glucose and fatty acid. CCN2 acted via the TrkA receptor. These data are the subject of this commentary, and emphasize that CCN2 may be an excellent target for therapy in diabetes.
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spelling pubmed-28214792010-02-19 Getting to the heart of the matter: CCN2 plays a role in cardiomyocyte hypertrophy Leask, Andrew J Cell Commun Signal Bits and Bytes Connective tissue growth factor (CTGF/CCN2) is overexpressed in diabetes. Diabetic rats possess myocardial and cardiomyocyte hypertrophy. In a recent report, Wang and colleagues (Am J Physiol Cell Physiol. 2009 Jul 22. [Epub ahead of print]) show that CCN2 directly mediates cardiomyocyte hypertrophy as well as that induced by high glucose and fatty acid. CCN2 acted via the TrkA receptor. These data are the subject of this commentary, and emphasize that CCN2 may be an excellent target for therapy in diabetes. Springer Netherlands 2009-08-24 2010-03 /pmc/articles/PMC2821479/ /pubmed/19701807 http://dx.doi.org/10.1007/s12079-009-0061-7 Text en © The Author(s) 2009 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Bits and Bytes
Leask, Andrew
Getting to the heart of the matter: CCN2 plays a role in cardiomyocyte hypertrophy
title Getting to the heart of the matter: CCN2 plays a role in cardiomyocyte hypertrophy
title_full Getting to the heart of the matter: CCN2 plays a role in cardiomyocyte hypertrophy
title_fullStr Getting to the heart of the matter: CCN2 plays a role in cardiomyocyte hypertrophy
title_full_unstemmed Getting to the heart of the matter: CCN2 plays a role in cardiomyocyte hypertrophy
title_short Getting to the heart of the matter: CCN2 plays a role in cardiomyocyte hypertrophy
title_sort getting to the heart of the matter: ccn2 plays a role in cardiomyocyte hypertrophy
topic Bits and Bytes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821479/
https://www.ncbi.nlm.nih.gov/pubmed/19701807
http://dx.doi.org/10.1007/s12079-009-0061-7
work_keys_str_mv AT leaskandrew gettingtotheheartofthematterccn2playsaroleincardiomyocytehypertrophy

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