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Bile Acid Sequestrants for Lipid and Glucose Control

Bile acids are generated in the liver and are traditionally recognized for their regulatory role in multiple metabolic processes including bile acid homeostasis, nutrient absorption, and cholesterol homeostasis. Recently, bile acids emerged as signaling molecules that, as ligands for the bile acid r...

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Detalles Bibliográficos
Autores principales: Staels, Bart, Handelsman, Yehuda, Fonseca, Vivian
Formato: Texto
Lenguaje:English
Publicado: Current Science Inc. 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821506/
https://www.ncbi.nlm.nih.gov/pubmed/20425070
http://dx.doi.org/10.1007/s11892-009-0087-5
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author Staels, Bart
Handelsman, Yehuda
Fonseca, Vivian
author_facet Staels, Bart
Handelsman, Yehuda
Fonseca, Vivian
author_sort Staels, Bart
collection PubMed
description Bile acids are generated in the liver and are traditionally recognized for their regulatory role in multiple metabolic processes including bile acid homeostasis, nutrient absorption, and cholesterol homeostasis. Recently, bile acids emerged as signaling molecules that, as ligands for the bile acid receptors farnesoid X receptor (FXR) and TGR5, activate and integrate multiple complex signaling pathways involved in lipid and glucose metabolism. Bile acid sequestrants are pharmacologic molecules that bind to bile acids in the intestine resulting in the interruption of bile acid homeostasis and, consequently, reduction in low-density lipoprotein cholesterol levels in hypercholesterolemia. Bile acid sequestrants also reduce glucose levels and improve glycemic control in persons with type 2 diabetes mellitus (T2DM). This article examines the mechanisms by which bile acid–mediated activation of FXR and TGR5 signaling pathways regulate lipid and glucose metabolism and the potential implications for bile acid sequestrant–mediated regulation of lipid and glucose levels in T2DM.
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spelling pubmed-28215062010-02-19 Bile Acid Sequestrants for Lipid and Glucose Control Staels, Bart Handelsman, Yehuda Fonseca, Vivian Curr Diab Rep Article Bile acids are generated in the liver and are traditionally recognized for their regulatory role in multiple metabolic processes including bile acid homeostasis, nutrient absorption, and cholesterol homeostasis. Recently, bile acids emerged as signaling molecules that, as ligands for the bile acid receptors farnesoid X receptor (FXR) and TGR5, activate and integrate multiple complex signaling pathways involved in lipid and glucose metabolism. Bile acid sequestrants are pharmacologic molecules that bind to bile acids in the intestine resulting in the interruption of bile acid homeostasis and, consequently, reduction in low-density lipoprotein cholesterol levels in hypercholesterolemia. Bile acid sequestrants also reduce glucose levels and improve glycemic control in persons with type 2 diabetes mellitus (T2DM). This article examines the mechanisms by which bile acid–mediated activation of FXR and TGR5 signaling pathways regulate lipid and glucose metabolism and the potential implications for bile acid sequestrant–mediated regulation of lipid and glucose levels in T2DM. Current Science Inc. 2010-01-22 2010 /pmc/articles/PMC2821506/ /pubmed/20425070 http://dx.doi.org/10.1007/s11892-009-0087-5 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Staels, Bart
Handelsman, Yehuda
Fonseca, Vivian
Bile Acid Sequestrants for Lipid and Glucose Control
title Bile Acid Sequestrants for Lipid and Glucose Control
title_full Bile Acid Sequestrants for Lipid and Glucose Control
title_fullStr Bile Acid Sequestrants for Lipid and Glucose Control
title_full_unstemmed Bile Acid Sequestrants for Lipid and Glucose Control
title_short Bile Acid Sequestrants for Lipid and Glucose Control
title_sort bile acid sequestrants for lipid and glucose control
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821506/
https://www.ncbi.nlm.nih.gov/pubmed/20425070
http://dx.doi.org/10.1007/s11892-009-0087-5
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