T-Lymphocyte Subsets in Apparently Healthy Nigerian Children

Population studies showed that there are differences in T-lymphocytes subpopulation of normal children in different regions, and reference values in an area might be different from another. This study compared the values in our population with CDC and WHO reference values. Blood samples from 279 hea...

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Detalles Bibliográficos
Autores principales: Idigbe, Emmanuel Oni, Audu, Rosemary A., Iroha, Edna O., Akinsulie, Adebola O., Temiye, Edamisan Olusoji, Ezeaka, Veronica C., Adetifa, Ifedayo M. O., Musa, Adesola Z., Onyewuche, Joseph, Ikondu, Sylvester U.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821635/
https://www.ncbi.nlm.nih.gov/pubmed/20169116
http://dx.doi.org/10.1155/2010/474380
Descripción
Sumario:Population studies showed that there are differences in T-lymphocytes subpopulation of normal children in different regions, and reference values in an area might be different from another. This study compared the values in our population with CDC and WHO reference values. Blood samples from 279 healthy, HIV-negative children <12 years of age were analysed for complete blood count, CD3+, CD4+, CD8+ counts and percentages. Except for CD8%, mean values for all parameters measured significantly decreased with age. CD4+ counts were higher in females than males, P < .05. Using the WHO criteria, 15.9% of subjects had low total lymphocyte count and 20.6% had low CD4 count. Children <3 years had median CD4% lower than WHO normal values. Our median CD4+ counts correlated with CDC values. Values used by WHO in infants are higher than ours. We suggest that our children be assessed using CDC reference values which correlate with ours.

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