Neutrophil Elastase-Mediated Degradation of IRS-1 Accelerates Lung Tumor Growth

Lung cancer is the leading cause of cancer death worldwide1. Recent data suggest that tumor-associated inflammatory cells may modify lung tumor growth and invasiveness2-3. To determine the role of neutrophil elastase (NE or Elane) on tumor progression, we utilized the LSL-K-ras model of murine lung...

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Detalles Bibliográficos
Autores principales: Houghton, A. McGarry, Rzymkiewicz, Danuta M., Ji, Hongbin, Gregory, Alyssa D., Egea, Eduardo E., Metz, Heather E., Stolz, Donna B., Land, Stephanie R., Marconcini, Luiz A., Kliment, Corrine R., Jenkins, Kimberly M., Beaulieu, Keith A., Mouded, Majd, Frank, Stuart J., Wong, Kwok K., Shapiro, Steven D.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821801/
https://www.ncbi.nlm.nih.gov/pubmed/20081861
http://dx.doi.org/10.1038/nm.2084

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