Prolonged Graft Survival in Older Recipient Mice Is Determined by Impaired Effector T-Cell but Intact Regulatory T-Cell Responses

Elderly organ transplant recipients represent a fast growing segment of patients on the waiting list. We examined age-dependent CD4(+) T-cell functions in a wild-type (WT) and a transgenic mouse transplant model and analyzed the suppressive function of old regulatory T-cells. We found that splenocyt...

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Detalles Bibliográficos
Autores principales: Denecke, Christian, Bedi, Damanpreet Singh, Ge, Xupeng, Kim, Irene Kyung-eun, Jurisch, Anke, Weiland, Anne, Habicht, Antje, Li, Xian C., Tullius, Stefan G.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821908/
https://www.ncbi.nlm.nih.gov/pubmed/20169060
http://dx.doi.org/10.1371/journal.pone.0009232

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