Cargando…

Modulation of Alpha-Synuclein Aggregation by Dopamine Analogs

The action of dopamine on the aggregation of the unstructured alpha-synuclein (α-syn) protein may be linked to the pathogenesis of Parkinson's disease. Dopamine and its oxidation derivatives may inhibit α-syn aggregation by non-covalent binding. Exploiting this fact, we applied an integrated co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Latawiec, Diane, Herrera, Fernando, Bek, Alpan, Losasso, Valeria, Candotti, Michela, Benetti, Federico, Carlino, Elvio, Kranjc, Agata, Lazzarino, Marco, Gustincich, Stefano, Carloni, Paolo, Legname, Giuseppe
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821914/ https://www.ncbi.nlm.nih.gov/pubmed/20169066 http://dx.doi.org/10.1371/journal.pone.0009234

Ejemplares similares

Inhibition of α-Synuclein Fibrillization by Dopamine Is Mediated by Interactions with Five C-Terminal Residues and with E83 in the NAC Region
por: Herrera, Fernando E., et al.
Publicado: (2008)

Effect of curcumin analogs onα-synuclein aggregation and cytotoxicity
por: Jha, Narendra Nath, et al.
Publicado: (2016)

In vitro aggregation assays for the characterization of α-synuclein prion-like properties
por: Narkiewicz, Joanna, et al.
Publicado: (2014)

Profiling Dopamine-Induced Oxidized Proteoforms of β-synuclein by Top-Down Mass Spectrometry
por: Luise, Arianna, et al.
Publicado: (2021)

Defined α-synuclein prion-like molecular assemblies spreading in cell culture
por: Aulić, Suzana, et al.
Publicado: (2014)

CSPα reduces aggregates and rescues striatal dopamine release in α-synuclein transgenic mice
por: Caló, Laura, et al.
Publicado: (2021)

Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo
por: Albert, Katrina, et al.
Publicado: (2021)

Neuronal haemoglobin induces loss of dopaminergic neurons in mouse Substantia nigra, cognitive deficits and cleavage of endogenous α-synuclein
por: Santulli, Chiara, et al.
Publicado: (2022)

The Aggregation of Huntingtin and α-Synuclein
por: Chánez-Cárdenas, María Elena, et al.
Publicado: (2012)

Monitoring α-synuclein aggregation
por: Estaun-Panzano, Juan, et al.
Publicado: (2023)

A Molotov cocktail: dopamine and α-synuclein
por: Tuma, Rabiya
Publicado: (2002)

Dopamine-Induced Conformational Changes in Alpha-Synuclein
por: Outeiro, Tiago F., et al.
Publicado: (2009)

SUMOylation of Alpha-Synuclein Influences on Alpha-Synuclein Aggregation Induced by Methamphetamine
por: Zhu, Lin-nan, et al.
Publicado: (2018)

Acceleration of α-Synuclein Aggregation by Exosomes
por: Grey, Marie, et al.
Publicado: (2015)

Alpha-Synuclein Aggregation in Parkinson's Disease
por: Srinivasan, E., et al.
Publicado: (2021)

Aggregation and neurotoxicity of recombinant α-synuclein aggregates initiated by dimerization
por: Roostaee, Alireza, et al.
Publicado: (2013)

New insights into structural determinants of prion protein folding and stability
por: Benetti, Federico, et al.
Publicado: (2015)

Inhibition of alpha-synuclein aggregation by multifunctional dopamine agonists assessed by a novel in vitro assay and an in vivo Drosophila synucleinopathy model
por: Yedlapudi, Deepthi, et al.
Publicado: (2016)

Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model
por: Wegrzynowicz, Michal, et al.
Publicado: (2019)

α-Synuclein Aggregates Increase the Conductance of Substantia Nigra Dopamine Neurons, an Effect Partly Reversed by the KATP Channel Inhibitor Glibenclamide
por: Hill, E., et al.
Publicado: (2021)

The Convergence of Dopamine and α-Synuclein: Implications for Parkinson’s Disease
por: Mor, Danielle E, et al.
Publicado: (2018)

Dopamine, Alpha-Synuclein, and Mitochondrial Dysfunctions in Parkinsonian Eyes
por: Indrieri, Alessia, et al.
Publicado: (2020)

Improvement of Laser-Crystallized Silicon Film Quality via Intermediate Dielectric Layers on a Glass Substrate
por: ÇINAR, Kamil, et al.
Publicado: (2018)

The Interplay of Cholesterol and Ligand Binding in hTSPO from Classical Molecular Dynamics Simulations
por: Lai, Hien T. T., et al.
Publicado: (2021)

Unveiling a Selective Mechanism for the Inhibition of α-Synuclein Aggregation by β-Synuclein
por: Leitao, Andre, et al.
Publicado: (2018)

Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation
por: Scheibe, Christian, et al.
Publicado: (2021)

Dopamine-Mediated Oxidation of Methionine 127 in α-Synuclein Causes Cytotoxicity and Oligomerization of α-Synuclein
por: Nakaso, Kazuhiro, et al.
Publicado: (2013)

Alpha-synuclein is strategically positioned for afferent modulation of midbrain dopamine neurons and is essential for cocaine preference
por: Trubetckaia, Olga, et al.
Publicado: (2019)

Sumoylation inhibits α-synuclein aggregation and toxicity
por: Krumova, Petranka, et al.
Publicado: (2011)

Models of α-synuclein aggregation in Parkinson’s disease
por: Giráldez-Pérez, Rosa María, et al.
Publicado: (2014)

Insights Into Peptide Inhibition of Alpha-Synuclein Aggregation
por: Torpey, James H., et al.
Publicado: (2020)

The Effects of Lipids on α-Synuclein Aggregation In Vitro
por: Ramirez, Jennifer, et al.
Publicado: (2023)

Tau Enhances α-Synuclein Aggregation and Toxicity in Cellular Models of Synucleinopathy
por: Badiola, Nahuai, et al.
Publicado: (2011)

Inducing α-synuclein compaction: a new strategy for inhibiting α-synuclein aggregation?
por: Pinheiro, Francisca, et al.
Publicado: (2019)

Alpha-Synuclein FRET Biosensors Reveal Early Alpha-Synuclein Aggregation in the Endoplasmic Reticulum
por: Miraglia, Fabiana, et al.
Publicado: (2020)

Dopamine and α-synuclein dysfunction in Smad3 null mice
por: Tapia-González, Silvia, et al.
Publicado: (2011)

Binding of Dopamine to Alpha-Synuclein is Mediated by Specific Conformational States
por: Illes-Toth, Eva, et al.
Publicado: (2013)

Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration
por: Mor, Danielle E., et al.
Publicado: (2017)

Monitoring α-synuclein Aggregation Induced by Preformed α-synuclein Fibrils in an In Vitro Model System
por: Kim, Beom Jin, et al.
Publicado: (2023)

Membrane Lipid Co-Aggregation with α-Synuclein Fibrils
por: Hellstrand, Erik, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_kvjtvhj7rpgohc6t7ple03b9fa