Altered Thymic Selection by Over-Expressing Cellular FLICE Inhibitory Protein in T Cells Causes Lupus-like Syndrome in BALB/c but not C57BL/6 Strain

Cellular FLICE inhibitory protein (c-FLIP) is an endogenous inhibitor of the caspase-8 pro-apoptotic signaling pathway downstream of death receptors. Recent evidence indicates that the long form of c-FLIP (c-FLIP(L)) is required for proliferation and effector T cell development. However, the role of...

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Detalles Bibliográficos
Autores principales: Qiao, Guilin, Li, Zhenping, Minto, Andrew W., Shia, Jinru, Yang, Lifen, Bao, Lihua, Tschopp, Jurg, Gao, Jian-Xin, Wang, Jimin, Quigg, Richard J., Zhang, Jian
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822025/
https://www.ncbi.nlm.nih.gov/pubmed/19816511
http://dx.doi.org/10.1038/cdd.2009.143

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