Carbon metabolism-mediated myogenic differentiation

The role of nutrients and metabolism in cellular differentiation is poorly understood. Using RNAi screening, metabolic profiling and small-molecule probes, we discovered three metabolic enzymes whose knockdown induces differentiation of mouse C2C12 myoblasts even in the presence mitogens: phosphogly...

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Detalles Bibliográficos
Autores principales: Bracha, Abigail L., Ramanathan, Arvind, Huang, Sui, Ingber, Donald E., Schreiber, Stuart L.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822028/
https://www.ncbi.nlm.nih.gov/pubmed/20081855
http://dx.doi.org/10.1038/nchembio.301
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author Bracha, Abigail L.
Ramanathan, Arvind
Huang, Sui
Ingber, Donald E.
Schreiber, Stuart L.
author_facet Bracha, Abigail L.
Ramanathan, Arvind
Huang, Sui
Ingber, Donald E.
Schreiber, Stuart L.
author_sort Bracha, Abigail L.
collection PubMed
description The role of nutrients and metabolism in cellular differentiation is poorly understood. Using RNAi screening, metabolic profiling and small-molecule probes, we discovered three metabolic enzymes whose knockdown induces differentiation of mouse C2C12 myoblasts even in the presence mitogens: phosphoglycerate kinase (Pgk1), hexose-6-phosphate dehydrogenase (H6pd) and ATP citrate lyase (Acl). These enzymes and the pathways they regulate provide novel targets for the control of myogenic differentiation in myoblasts and rhabdomyosarcoma cells.
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spelling pubmed-28220282010-09-01 Carbon metabolism-mediated myogenic differentiation Bracha, Abigail L. Ramanathan, Arvind Huang, Sui Ingber, Donald E. Schreiber, Stuart L. Nat Chem Biol Article The role of nutrients and metabolism in cellular differentiation is poorly understood. Using RNAi screening, metabolic profiling and small-molecule probes, we discovered three metabolic enzymes whose knockdown induces differentiation of mouse C2C12 myoblasts even in the presence mitogens: phosphoglycerate kinase (Pgk1), hexose-6-phosphate dehydrogenase (H6pd) and ATP citrate lyase (Acl). These enzymes and the pathways they regulate provide novel targets for the control of myogenic differentiation in myoblasts and rhabdomyosarcoma cells. 2010-01-17 2010-03 /pmc/articles/PMC2822028/ /pubmed/20081855 http://dx.doi.org/10.1038/nchembio.301 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Bracha, Abigail L.
Ramanathan, Arvind
Huang, Sui
Ingber, Donald E.
Schreiber, Stuart L.
Carbon metabolism-mediated myogenic differentiation
title Carbon metabolism-mediated myogenic differentiation
title_full Carbon metabolism-mediated myogenic differentiation
title_fullStr Carbon metabolism-mediated myogenic differentiation
title_full_unstemmed Carbon metabolism-mediated myogenic differentiation
title_short Carbon metabolism-mediated myogenic differentiation
title_sort carbon metabolism-mediated myogenic differentiation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822028/
https://www.ncbi.nlm.nih.gov/pubmed/20081855
http://dx.doi.org/10.1038/nchembio.301
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AT schreiberstuartl carbonmetabolismmediatedmyogenicdifferentiation

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