Influence of Salvia miltiorrhizae on the Mesenteric Lymph Node of Rats with Severe Acute Pancreatitis or Obstructive Jaundice

Objective. To observe the effect of salvia miltiorrhizae injection on inflammatory mediator levels and mesenteric lymph nodes in severe acute pancreatitis (SAP) and obstructive jaundice (OJ) rats and explore the protective mechanism of salvia miltiorrhizae on the lymph nodes of these rats. Methods....

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Detalles Bibliográficos
Autores principales: Xiping, Zhang, Jie, Zhang, Shuyun, Ye, Qili, Wang, Guanghua, Feng, Yan, Pan
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822241/
https://www.ncbi.nlm.nih.gov/pubmed/20169004
http://dx.doi.org/10.1155/2009/675195
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author Xiping, Zhang
Jie, Zhang
Shuyun, Ye
Qili, Wang
Guanghua, Feng
Yan, Pan
author_facet Xiping, Zhang
Jie, Zhang
Shuyun, Ye
Qili, Wang
Guanghua, Feng
Yan, Pan
author_sort Xiping, Zhang
collection PubMed
description Objective. To observe the effect of salvia miltiorrhizae injection on inflammatory mediator levels and mesenteric lymph nodes in severe acute pancreatitis (SAP) and obstructive jaundice (OJ) rats and explore the protective mechanism of salvia miltiorrhizae on the lymph nodes of these rats. Methods. A total of 288 rats were used in SAP-associated and OJ-associated experiments. The rats were randomly divided into sham-operated group, model control group, and treated group. At various time points after operation, the pathological changes in mesenteric lymph nodes of rats in each group were observed, respectively. Results. The pathological severity scores in lymph nodes of SAP rats in treated group were significantly lower than those in model control group (P < .05) while the pathological changes in lymph nodes of OJ rats in treated group also showed varying degrees of mitigation. Conclusion. Salvia miltiorrhizae can exert protective effects on the lymph nodes of SAP or OJ rats via a mechanism that is associated with reducing the contents of inflammatory mediators in blood.
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spelling pubmed-28222412010-02-18 Influence of Salvia miltiorrhizae on the Mesenteric Lymph Node of Rats with Severe Acute Pancreatitis or Obstructive Jaundice Xiping, Zhang Jie, Zhang Shuyun, Ye Qili, Wang Guanghua, Feng Yan, Pan Mediators Inflamm Research Article Objective. To observe the effect of salvia miltiorrhizae injection on inflammatory mediator levels and mesenteric lymph nodes in severe acute pancreatitis (SAP) and obstructive jaundice (OJ) rats and explore the protective mechanism of salvia miltiorrhizae on the lymph nodes of these rats. Methods. A total of 288 rats were used in SAP-associated and OJ-associated experiments. The rats were randomly divided into sham-operated group, model control group, and treated group. At various time points after operation, the pathological changes in mesenteric lymph nodes of rats in each group were observed, respectively. Results. The pathological severity scores in lymph nodes of SAP rats in treated group were significantly lower than those in model control group (P < .05) while the pathological changes in lymph nodes of OJ rats in treated group also showed varying degrees of mitigation. Conclusion. Salvia miltiorrhizae can exert protective effects on the lymph nodes of SAP or OJ rats via a mechanism that is associated with reducing the contents of inflammatory mediators in blood. Hindawi Publishing Corporation 2009 2010-02-15 /pmc/articles/PMC2822241/ /pubmed/20169004 http://dx.doi.org/10.1155/2009/675195 Text en Copyright © 2009 Zhang Xiping et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Xiping, Zhang
Jie, Zhang
Shuyun, Ye
Qili, Wang
Guanghua, Feng
Yan, Pan
Influence of Salvia miltiorrhizae on the Mesenteric Lymph Node of Rats with Severe Acute Pancreatitis or Obstructive Jaundice
title Influence of Salvia miltiorrhizae on the Mesenteric Lymph Node of Rats with Severe Acute Pancreatitis or Obstructive Jaundice
title_full Influence of Salvia miltiorrhizae on the Mesenteric Lymph Node of Rats with Severe Acute Pancreatitis or Obstructive Jaundice
title_fullStr Influence of Salvia miltiorrhizae on the Mesenteric Lymph Node of Rats with Severe Acute Pancreatitis or Obstructive Jaundice
title_full_unstemmed Influence of Salvia miltiorrhizae on the Mesenteric Lymph Node of Rats with Severe Acute Pancreatitis or Obstructive Jaundice
title_short Influence of Salvia miltiorrhizae on the Mesenteric Lymph Node of Rats with Severe Acute Pancreatitis or Obstructive Jaundice
title_sort influence of salvia miltiorrhizae on the mesenteric lymph node of rats with severe acute pancreatitis or obstructive jaundice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822241/
https://www.ncbi.nlm.nih.gov/pubmed/20169004
http://dx.doi.org/10.1155/2009/675195
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