Meningeal Relapse in a Patient with Acute Promyelocytic Leukemia: A Case Report and Review of the Literature

The involvement of central nervous system is rare in acute promyelocytic leukemia (APL). We report a APL patient of a 41 yr-old Korean male who presented with fever and petechia. Complete molecular remission was achieved with all-trans retinoic acid (ATRA), idarubicin, and cytarabine. Ten months lat...

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Detalles Bibliográficos
Autores principales: Bae, Sung Hwa, Ryoo, Hun Mo, Cho, Hee Soon, Lee, Jae Lyun, Lee, Kyung Hee, Hyun, Myung Soo
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2004
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822320/
https://www.ncbi.nlm.nih.gov/pubmed/15082912
http://dx.doi.org/10.3346/jkms.2004.19.2.311
Descripción
Sumario:The involvement of central nervous system is rare in acute promyelocytic leukemia (APL). We report a APL patient of a 41 yr-old Korean male who presented with fever and petechia. Complete molecular remission was achieved with all-trans retinoic acid (ATRA), idarubicin, and cytarabine. Ten months later, he complained of a mild headache. The results of the physical examination and the complete blood counts were normal. The examination of cerebrospinal fluid showed the presence of promyelocyte. Bone marrow studies showed cytogenetic remission but with molecular relapse. He was treated with intrathecal and systemic chemotherapy.

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