Meningeal Relapse in a Patient with Acute Promyelocytic Leukemia: A Case Report and Review of the Literature

The involvement of central nervous system is rare in acute promyelocytic leukemia (APL). We report a APL patient of a 41 yr-old Korean male who presented with fever and petechia. Complete molecular remission was achieved with all-trans retinoic acid (ATRA), idarubicin, and cytarabine. Ten months lat...

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Detalles Bibliográficos
Autores principales: Bae, Sung Hwa, Ryoo, Hun Mo, Cho, Hee Soon, Lee, Jae Lyun, Lee, Kyung Hee, Hyun, Myung Soo
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2004
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822320/
https://www.ncbi.nlm.nih.gov/pubmed/15082912
http://dx.doi.org/10.3346/jkms.2004.19.2.311
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author Bae, Sung Hwa
Ryoo, Hun Mo
Cho, Hee Soon
Lee, Jae Lyun
Lee, Kyung Hee
Hyun, Myung Soo
author_facet Bae, Sung Hwa
Ryoo, Hun Mo
Cho, Hee Soon
Lee, Jae Lyun
Lee, Kyung Hee
Hyun, Myung Soo
author_sort Bae, Sung Hwa
collection PubMed
description The involvement of central nervous system is rare in acute promyelocytic leukemia (APL). We report a APL patient of a 41 yr-old Korean male who presented with fever and petechia. Complete molecular remission was achieved with all-trans retinoic acid (ATRA), idarubicin, and cytarabine. Ten months later, he complained of a mild headache. The results of the physical examination and the complete blood counts were normal. The examination of cerebrospinal fluid showed the presence of promyelocyte. Bone marrow studies showed cytogenetic remission but with molecular relapse. He was treated with intrathecal and systemic chemotherapy.
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spelling pubmed-28223202010-02-16 Meningeal Relapse in a Patient with Acute Promyelocytic Leukemia: A Case Report and Review of the Literature Bae, Sung Hwa Ryoo, Hun Mo Cho, Hee Soon Lee, Jae Lyun Lee, Kyung Hee Hyun, Myung Soo J Korean Med Sci Case Report The involvement of central nervous system is rare in acute promyelocytic leukemia (APL). We report a APL patient of a 41 yr-old Korean male who presented with fever and petechia. Complete molecular remission was achieved with all-trans retinoic acid (ATRA), idarubicin, and cytarabine. Ten months later, he complained of a mild headache. The results of the physical examination and the complete blood counts were normal. The examination of cerebrospinal fluid showed the presence of promyelocyte. Bone marrow studies showed cytogenetic remission but with molecular relapse. He was treated with intrathecal and systemic chemotherapy. The Korean Academy of Medical Sciences 2004-04 2004-04-30 /pmc/articles/PMC2822320/ /pubmed/15082912 http://dx.doi.org/10.3346/jkms.2004.19.2.311 Text en Copyright © 2004 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Bae, Sung Hwa
Ryoo, Hun Mo
Cho, Hee Soon
Lee, Jae Lyun
Lee, Kyung Hee
Hyun, Myung Soo
Meningeal Relapse in a Patient with Acute Promyelocytic Leukemia: A Case Report and Review of the Literature
title Meningeal Relapse in a Patient with Acute Promyelocytic Leukemia: A Case Report and Review of the Literature
title_full Meningeal Relapse in a Patient with Acute Promyelocytic Leukemia: A Case Report and Review of the Literature
title_fullStr Meningeal Relapse in a Patient with Acute Promyelocytic Leukemia: A Case Report and Review of the Literature
title_full_unstemmed Meningeal Relapse in a Patient with Acute Promyelocytic Leukemia: A Case Report and Review of the Literature
title_short Meningeal Relapse in a Patient with Acute Promyelocytic Leukemia: A Case Report and Review of the Literature
title_sort meningeal relapse in a patient with acute promyelocytic leukemia: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822320/
https://www.ncbi.nlm.nih.gov/pubmed/15082912
http://dx.doi.org/10.3346/jkms.2004.19.2.311
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