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Meningeal Relapse in a Patient with Acute Promyelocytic Leukemia: A Case Report and Review of the Literature
The involvement of central nervous system is rare in acute promyelocytic leukemia (APL). We report a APL patient of a 41 yr-old Korean male who presented with fever and petechia. Complete molecular remission was achieved with all-trans retinoic acid (ATRA), idarubicin, and cytarabine. Ten months lat...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Korean Academy of Medical Sciences
2004
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822320/ https://www.ncbi.nlm.nih.gov/pubmed/15082912 http://dx.doi.org/10.3346/jkms.2004.19.2.311 |
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author | Bae, Sung Hwa Ryoo, Hun Mo Cho, Hee Soon Lee, Jae Lyun Lee, Kyung Hee Hyun, Myung Soo |
author_facet | Bae, Sung Hwa Ryoo, Hun Mo Cho, Hee Soon Lee, Jae Lyun Lee, Kyung Hee Hyun, Myung Soo |
author_sort | Bae, Sung Hwa |
collection | PubMed |
description | The involvement of central nervous system is rare in acute promyelocytic leukemia (APL). We report a APL patient of a 41 yr-old Korean male who presented with fever and petechia. Complete molecular remission was achieved with all-trans retinoic acid (ATRA), idarubicin, and cytarabine. Ten months later, he complained of a mild headache. The results of the physical examination and the complete blood counts were normal. The examination of cerebrospinal fluid showed the presence of promyelocyte. Bone marrow studies showed cytogenetic remission but with molecular relapse. He was treated with intrathecal and systemic chemotherapy. |
format | Text |
id | pubmed-2822320 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-28223202010-02-16 Meningeal Relapse in a Patient with Acute Promyelocytic Leukemia: A Case Report and Review of the Literature Bae, Sung Hwa Ryoo, Hun Mo Cho, Hee Soon Lee, Jae Lyun Lee, Kyung Hee Hyun, Myung Soo J Korean Med Sci Case Report The involvement of central nervous system is rare in acute promyelocytic leukemia (APL). We report a APL patient of a 41 yr-old Korean male who presented with fever and petechia. Complete molecular remission was achieved with all-trans retinoic acid (ATRA), idarubicin, and cytarabine. Ten months later, he complained of a mild headache. The results of the physical examination and the complete blood counts were normal. The examination of cerebrospinal fluid showed the presence of promyelocyte. Bone marrow studies showed cytogenetic remission but with molecular relapse. He was treated with intrathecal and systemic chemotherapy. The Korean Academy of Medical Sciences 2004-04 2004-04-30 /pmc/articles/PMC2822320/ /pubmed/15082912 http://dx.doi.org/10.3346/jkms.2004.19.2.311 Text en Copyright © 2004 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Bae, Sung Hwa Ryoo, Hun Mo Cho, Hee Soon Lee, Jae Lyun Lee, Kyung Hee Hyun, Myung Soo Meningeal Relapse in a Patient with Acute Promyelocytic Leukemia: A Case Report and Review of the Literature |
title | Meningeal Relapse in a Patient with Acute Promyelocytic Leukemia: A Case Report and Review of the Literature |
title_full | Meningeal Relapse in a Patient with Acute Promyelocytic Leukemia: A Case Report and Review of the Literature |
title_fullStr | Meningeal Relapse in a Patient with Acute Promyelocytic Leukemia: A Case Report and Review of the Literature |
title_full_unstemmed | Meningeal Relapse in a Patient with Acute Promyelocytic Leukemia: A Case Report and Review of the Literature |
title_short | Meningeal Relapse in a Patient with Acute Promyelocytic Leukemia: A Case Report and Review of the Literature |
title_sort | meningeal relapse in a patient with acute promyelocytic leukemia: a case report and review of the literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822320/ https://www.ncbi.nlm.nih.gov/pubmed/15082912 http://dx.doi.org/10.3346/jkms.2004.19.2.311 |
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