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Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10

Type I interferon (IFN) α/β is critical for host defense. During endotoxicosis or highly lethal bacterial infections where systemic inflammation predominates, mice deficient in IFN-α/β receptor (IFNAR) display decreased systemic inflammation and improved outcome. However, human sepsis mortality ofte...

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Detalles Bibliográficos
Autores principales:	Kelly-Scumpia, Kindra M., Scumpia, Philip O., Delano, Matthew J., Weinstein, Jason S., Cuenca, Alex G., Wynn, James L., Moldawer, Lyle L.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2010
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822595/ https://www.ncbi.nlm.nih.gov/pubmed/20071504 http://dx.doi.org/10.1084/jem.20091959

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