Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging

Defects in the DNA repair mechanism nucleotide excision repair (NER) may lead to tumors in xeroderma pigmentosum (XP) or to premature aging with loss of subcutaneous fat in Cockayne syndrome (CS). Mutations of mitochondrial (mt)DNA play a role in aging, but a link between the NER-associated CS prote...

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Detalles Bibliográficos
Autores principales: Kamenisch, York, Fousteri, Maria, Knoch, Jennifer, von Thaler, Anna-Katharina, Fehrenbacher, Birgit, Kato, Hiroki, Becker, Thomas, Dollé, Martijn E.T., Kuiper, Raoul, Majora, Marc, Schaller, Martin, van der Horst, Gijsbertus T.J., van Steeg, Harry, Röcken, Martin, Rapaport, Doron, Krutmann, Jean, Mullenders, Leon H., Berneburg, Mark
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822596/
https://www.ncbi.nlm.nih.gov/pubmed/20100872
http://dx.doi.org/10.1084/jem.20091834

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