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Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4
The classical nonhomologous end-joining (C-NHEJ) DNA double-strand break (DSB) repair pathway employs the Ku70/80 complex (Ku) for DSB recognition and the XRCC4/DNA ligase 4 (Lig4) complex for ligation. During IgH class switch recombination (CSR) in B lymphocytes, switch (S) region DSBs are joined b...
Autores principales: | Boboila, Cristian, Yan, Catherine, Wesemann, Duane R., Jankovic, Mila, Wang, Jing H., Manis, John, Nussenzweig, Andre, Nussenzweig, Michel, Alt, Frederick W. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822597/ https://www.ncbi.nlm.nih.gov/pubmed/20142431 http://dx.doi.org/10.1084/jem.20092449 |
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