Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4

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The classical nonhomologous end-joining (C-NHEJ) DNA double-strand break (DSB) repair pathway employs the Ku70/80 complex (Ku) for DSB recognition and the XRCC4/DNA ligase 4 (Lig4) complex for ligation. During IgH class switch recombination (CSR) in B lymphocytes, switch (S) region DSBs are joined b...

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Detalles Bibliográficos
Autores principales: Boboila, Cristian, Yan, Catherine, Wesemann, Duane R., Jankovic, Mila, Wang, Jing H., Manis, John, Nussenzweig, Andre, Nussenzweig, Michel, Alt, Frederick W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822597/
https://www.ncbi.nlm.nih.gov/pubmed/20142431
http://dx.doi.org/10.1084/jem.20092449
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