Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile

The CD40–CD40 ligand (CD40L) signaling axis plays an important role in immunological pathways. Consequently, this dyad is involved in chronic inflammatory diseases, including atherosclerosis. Inhibition of CD40L in apolipoprotein E (Apoe)–deficient (Apoe(−/−)) mice not only reduced atherosclerosis b...

Descripción completa

Detalles Bibliográficos
Autores principales: Lutgens, Esther, Lievens, Dirk, Beckers, Linda, Wijnands, Erwin, Soehnlein, Oliver, Zernecke, Alma, Seijkens, Tom, Engel, David, Cleutjens, Jack, Keller, Anna M., Naik, Shalin H., Boon, Louis, Oufella, Hafid Ait, Mallat, Ziad, Ahonen, Cory L., Noelle, Randolph J., de Winther, Menno P., Daemen, Mat J., Biessen, Erik A., Weber, Christian
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822598/
https://www.ncbi.nlm.nih.gov/pubmed/20100871
http://dx.doi.org/10.1084/jem.20091293

Ejemplares similares

Ejemplares similares