Natural killer receptors: the burden of a name

A population of cells that expresses the NK cell receptor NKp46 and produces interleukin (IL)-22 have recently attracted considerable attention. The identity of these cells is still the subject of speculation, being variably defined as a novel NK cell subset or as a population containing conventiona...

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Detalles Bibliográficos
Autores principales: Veiga-Fernandes, Henrique, Kioussis, Dimitris, Coles, Mark
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822611/
https://www.ncbi.nlm.nih.gov/pubmed/20142428
http://dx.doi.org/10.1084/jem.20100105
Descripción
Sumario:A population of cells that expresses the NK cell receptor NKp46 and produces interleukin (IL)-22 have recently attracted considerable attention. The identity of these cells is still the subject of speculation, being variably defined as a novel NK cell subset or as a population containing conventional NK (cNK) cell precursors. In this issue, two studies shed light on this conundrum, demonstrating that NKp46(+) IL-22(+) cells and cNK cells belong to distinct lineages.

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