Pharmacological prion protein silencing accelerates central nervous system autoimmune disease via T cell receptor signalling

The primary biological function of the endogenous cellular prion protein has remained unclear. We investigated its biological function in the generation of cellular immune responses using cellular prion protein gene-specific small interfering ribonucleic acid in vivo and in vitro. Our results were c...

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Detalles Bibliográficos
Autores principales: Hu, Wei, Nessler, Stefan, Hemmer, Bernhard, Eagar, Todd N., Kane, Lawrence P., Leliveld, S. Rutger, Müller-Schiffmann, Andreas, Gocke, Anne R., Lovett-Racke, Amy, Ben, Li-Hong, Hussain, Rehana Z., Breil, Andreas, Elliott, Jeffrey L., Puttaparthi, Krishna, Cravens, Petra D., Singh, Mahendra P., Petsch, Benjamin, Stitz, Lothar, Racke, Michael K., Korth, Carsten, Stüve, Olaf
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822628/
https://www.ncbi.nlm.nih.gov/pubmed/20145049
http://dx.doi.org/10.1093/brain/awp298

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