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Transcranial sonography for diagnosis of Parkinson's disease

BACKGROUND: In idiopathic Parkinson's disease (IPD) transcranial sonography (TCS) represents an alternative diagnostic method to verify clinical diagnosis. Although the phenomenon of an increased echogenicity of the Substantia nigra (SN) is well known this method is still not widly used in the...

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Autores principales: Mehnert, Sabine, Reuter, Iris, Schepp, Karsten, Maaser, Peter, Stolz, Erwin, Kaps, Manfred
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822767/
https://www.ncbi.nlm.nih.gov/pubmed/20089201
http://dx.doi.org/10.1186/1471-2377-10-9
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author Mehnert, Sabine
Reuter, Iris
Schepp, Karsten
Maaser, Peter
Stolz, Erwin
Kaps, Manfred
author_facet Mehnert, Sabine
Reuter, Iris
Schepp, Karsten
Maaser, Peter
Stolz, Erwin
Kaps, Manfred
author_sort Mehnert, Sabine
collection PubMed
description BACKGROUND: In idiopathic Parkinson's disease (IPD) transcranial sonography (TCS) represents an alternative diagnostic method to verify clinical diagnosis. Although the phenomenon of an increased echogenicity of the Substantia nigra (SN) is well known this method is still not widly used in the diagnostic workup. Until now reliability of this method is still a matter of debate, partly because data only existed from a few laboratories using the same ultrasound machine. Therefore our study was conducted to test the reliability of this method by using a different ultrasound device and examining a large population of control and IPD subjects by two examiners to calculate interobserver reliability. METHOD: In this study echogenicity of SN was examined in 199 IPD patients and 201 control subjects. All individuals underwent a neurological assessment including Perdue pegboard test and Webster gait test. Using a Sonos 5500 ultrasound device area of SN was measured, echogenicity of raphe, red nuclei, thalamus, caudate and lenticular nuclei, width of third and lateral ventricle were documented. RESULTS: We found a highly characteristic enlargement of the SN echogenic signal in IPD. The cut-off value for the SN area was established using a ROC curve with a sensitivity of 95% corresponding to an area of SN of 0.2 cm(2 )and was found to be equivalent to the cut-off values of other studies using different ultrasound devices. CONCLUSIONS: Our study shows that TCS is a reliable and highly sensitive tool for differentiation of IPD patients from individuals without CNS disorders.
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spelling pubmed-28227672010-02-17 Transcranial sonography for diagnosis of Parkinson's disease Mehnert, Sabine Reuter, Iris Schepp, Karsten Maaser, Peter Stolz, Erwin Kaps, Manfred BMC Neurol Research article BACKGROUND: In idiopathic Parkinson's disease (IPD) transcranial sonography (TCS) represents an alternative diagnostic method to verify clinical diagnosis. Although the phenomenon of an increased echogenicity of the Substantia nigra (SN) is well known this method is still not widly used in the diagnostic workup. Until now reliability of this method is still a matter of debate, partly because data only existed from a few laboratories using the same ultrasound machine. Therefore our study was conducted to test the reliability of this method by using a different ultrasound device and examining a large population of control and IPD subjects by two examiners to calculate interobserver reliability. METHOD: In this study echogenicity of SN was examined in 199 IPD patients and 201 control subjects. All individuals underwent a neurological assessment including Perdue pegboard test and Webster gait test. Using a Sonos 5500 ultrasound device area of SN was measured, echogenicity of raphe, red nuclei, thalamus, caudate and lenticular nuclei, width of third and lateral ventricle were documented. RESULTS: We found a highly characteristic enlargement of the SN echogenic signal in IPD. The cut-off value for the SN area was established using a ROC curve with a sensitivity of 95% corresponding to an area of SN of 0.2 cm(2 )and was found to be equivalent to the cut-off values of other studies using different ultrasound devices. CONCLUSIONS: Our study shows that TCS is a reliable and highly sensitive tool for differentiation of IPD patients from individuals without CNS disorders. BioMed Central 2010-01-21 /pmc/articles/PMC2822767/ /pubmed/20089201 http://dx.doi.org/10.1186/1471-2377-10-9 Text en Copyright ©2010 Mehnert et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research article
Mehnert, Sabine
Reuter, Iris
Schepp, Karsten
Maaser, Peter
Stolz, Erwin
Kaps, Manfred
Transcranial sonography for diagnosis of Parkinson's disease
title Transcranial sonography for diagnosis of Parkinson's disease
title_full Transcranial sonography for diagnosis of Parkinson's disease
title_fullStr Transcranial sonography for diagnosis of Parkinson's disease
title_full_unstemmed Transcranial sonography for diagnosis of Parkinson's disease
title_short Transcranial sonography for diagnosis of Parkinson's disease
title_sort transcranial sonography for diagnosis of parkinson's disease
topic Research article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822767/
https://www.ncbi.nlm.nih.gov/pubmed/20089201
http://dx.doi.org/10.1186/1471-2377-10-9
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