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Increased Sensitivity of CD4+ T-Effector Cells to CD4+CD25+ Treg Suppression Compensates for Reduced Treg Number in Asymptomatic HIV-1 Infection

BACKGROUND: In HIV infection, uncontrolled immune activation and disease progression is attributed to declining CD4+CD25+FoxP3+ regulatory T-cell (Treg) numbers. However, qualitative aspects of Treg function in HIV infection, specifically the balance between Treg cell suppressive potency versus supp...

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Detalles Bibliográficos
Autores principales:	Thorborn, Georgina, Pomeroy, Laura, Isohanni, Heidi, Perry, Melissa, Peters, Barry, Vyakarnam, Annapurna
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822868/ https://www.ncbi.nlm.nih.gov/pubmed/20174666 http://dx.doi.org/10.1371/journal.pone.0009254

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