Concurrent administration of heparin and activated protein C in a patient with pulmonary embolism and severe sepsis with positive outcome

Results of the PROWESS trial suggested that heparin may reduce the efficacy of recombinant human activated protein C (rhAPC) and the XPRESS study also showed increased bleeding complications in patients receiving heparin with rhAPC. Although it has been shown that heparin prophylaxis may be used alo...

Descripción completa

Detalles Bibliográficos
Autores principales: Juneja, Deven, Mohan, S., Veturi, Vivek V., Gopal, Palepu B.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2009
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823100/
https://www.ncbi.nlm.nih.gov/pubmed/20040816
http://dx.doi.org/10.4103/0972-5229.58544
_version_ 1782177597810016256
author Juneja, Deven
Mohan, S.
Veturi, Vivek V.
Gopal, Palepu B.
author_facet Juneja, Deven
Mohan, S.
Veturi, Vivek V.
Gopal, Palepu B.
author_sort Juneja, Deven
collection PubMed
description Results of the PROWESS trial suggested that heparin may reduce the efficacy of recombinant human activated protein C (rhAPC) and the XPRESS study also showed increased bleeding complications in patients receiving heparin with rhAPC. Although it has been shown that heparin prophylaxis may be used along with rhAPC, no study has shown the interaction between continuous heparin infusion and rhAPC. Here, we report a case of severe sepsis with pulmonary embolism who was concurrently administered heparin and rhAPC infusions, with positive results and no bleeding complications.
format Text
id pubmed-2823100
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Medknow Publications
record_format MEDLINE/PubMed
spelling pubmed-28231002010-02-17 Concurrent administration of heparin and activated protein C in a patient with pulmonary embolism and severe sepsis with positive outcome Juneja, Deven Mohan, S. Veturi, Vivek V. Gopal, Palepu B. Indian J Crit Care Med Case Report Results of the PROWESS trial suggested that heparin may reduce the efficacy of recombinant human activated protein C (rhAPC) and the XPRESS study also showed increased bleeding complications in patients receiving heparin with rhAPC. Although it has been shown that heparin prophylaxis may be used along with rhAPC, no study has shown the interaction between continuous heparin infusion and rhAPC. Here, we report a case of severe sepsis with pulmonary embolism who was concurrently administered heparin and rhAPC infusions, with positive results and no bleeding complications. Medknow Publications 2009 /pmc/articles/PMC2823100/ /pubmed/20040816 http://dx.doi.org/10.4103/0972-5229.58544 Text en © Indian Journal of Critical Care Medicine http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Juneja, Deven
Mohan, S.
Veturi, Vivek V.
Gopal, Palepu B.
Concurrent administration of heparin and activated protein C in a patient with pulmonary embolism and severe sepsis with positive outcome
title Concurrent administration of heparin and activated protein C in a patient with pulmonary embolism and severe sepsis with positive outcome
title_full Concurrent administration of heparin and activated protein C in a patient with pulmonary embolism and severe sepsis with positive outcome
title_fullStr Concurrent administration of heparin and activated protein C in a patient with pulmonary embolism and severe sepsis with positive outcome
title_full_unstemmed Concurrent administration of heparin and activated protein C in a patient with pulmonary embolism and severe sepsis with positive outcome
title_short Concurrent administration of heparin and activated protein C in a patient with pulmonary embolism and severe sepsis with positive outcome
title_sort concurrent administration of heparin and activated protein c in a patient with pulmonary embolism and severe sepsis with positive outcome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823100/
https://www.ncbi.nlm.nih.gov/pubmed/20040816
http://dx.doi.org/10.4103/0972-5229.58544
work_keys_str_mv AT junejadeven concurrentadministrationofheparinandactivatedproteincinapatientwithpulmonaryembolismandseveresepsiswithpositiveoutcome
AT mohans concurrentadministrationofheparinandactivatedproteincinapatientwithpulmonaryembolismandseveresepsiswithpositiveoutcome
AT veturivivekv concurrentadministrationofheparinandactivatedproteincinapatientwithpulmonaryembolismandseveresepsiswithpositiveoutcome
AT gopalpalepub concurrentadministrationofheparinandactivatedproteincinapatientwithpulmonaryembolismandseveresepsiswithpositiveoutcome

Ejemplares similares