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Molecular dynamics simulation of a human thiopurine S-methyltransferase complexed with 6-mercaptopurine model

Human thiopurine S-methyltransferase (TPMT) is an essential protein in 6-mercaptopurine (6MP) drug metabolism. To understand the pharmacogenetics of TPMT and 6MP, X-ray co-crystal structures of TPMT complexes with S-adenosyl-L-methionine (AdoMet) and 6MP are required. However, the co-crystal structu...

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Detalles Bibliográficos
Autores principales:	Mokmak, Wanwimon, Tongsima, Sissades, Jenwitheesuk, Ekachai
Formato:	Texto
Lenguaje:	English
Publicado:	Biomedical Informatics 2009
Materias:	Hypothesis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823381/ https://www.ncbi.nlm.nih.gov/pubmed/20198169

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