HNHDb: A database on pattern based classification of HNH domains reveals functional relevance of sequence patterns and domain associations.

The HNH Database is a collection and sequence-based classification of HNH domain proteins. The database contains about 1913 HNH domain containing proteins, and is classified into 10 subsets based on the sequence pattern. Each of these subsets has unique signature sequences. We have shown a correlati...

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Detalles Bibliográficos
Autores principales: Veluchamy, Alaguraj, Mary, Sujitha, Acharya, Vishal, Mehta, Preethi, Deva, Taru, Krishnaswamy, Sankaran
Formato: Texto
Lenguaje:English
Publicado: Biomedical Informatics 2009
Materias:
Database
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823387/
https://www.ncbi.nlm.nih.gov/pubmed/20198175
Descripción
Sumario:The HNH Database is a collection and sequence-based classification of HNH domain proteins. The database contains about 1913 HNH domain containing proteins, and is classified into 10 subsets based on the sequence pattern. Each of these subsets has unique signature sequences. We have shown a correlation between the subset combination and their domain association and function. Functional divergence of this domain may be due to the combination of these conserved patterns and the large variations in the non-conserved regions. HNHDb is freely available at http://bicmku.in:8081/hnh.

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