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Global Consequences of Activation Loop Phosphorylation on Protein Kinase A

Phosphorylation of the activation loop is one of the most common mechanisms for regulating protein kinase activity. The catalytic subunit of cAMP-dependent protein kinase autophosphorylates Thr(197) in the activation loop when expressed in Escherichia coli. Although mutation of Arg(194) to Ala preve...

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Detalles Bibliográficos
Autores principales:	Steichen, Jon M., Iyer, Ganesh H., Li, Sheng, Saldanha, S. Adrian, Deal, Michael S., Woods, Virgil L., Taylor, Susan S.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Enzyme Catalysis and Regulation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823524/ https://www.ncbi.nlm.nih.gov/pubmed/19965870 http://dx.doi.org/10.1074/jbc.M109.061820

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