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Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue

BACKGROUND: The human immunodeficiency virus type 1 (HIV-1) Vpu protein degrades CD4 and counteracts a restriction factor termed tetherin (CD317; Bst-2) to enhance virion release. It has been suggested that both functions can be genetically separated by mutation of a serine residue at position 52. H...

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Detalles Bibliográficos
Autores principales:	Schindler, Michael, Rajan, Devi, Banning, Carina, Wimmer, Peter, Koppensteiner, Herwig, Iwanski, Alicja, Specht, Anke, Sauter, Daniel, Dobner, Thomas, Kirchhoff, Frank
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823648/ https://www.ncbi.nlm.nih.gov/pubmed/20078884 http://dx.doi.org/10.1186/1742-4690-7-1

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