The Pin 1 inhibitor juglone attenuates kidney fibrogenesis via Pin 1-independent mechanisms in the unilateral ureteral occlusion model

BACKGROUND: Pin 1 is a peptidyl-prolyl isomerase inhibitor related to cyclophilin A and FK506 binding protein (FKBP). Juglone (5-hydroxy-1,4-naphthoquinone) is a natural inhibitor of Pin 1 with anti-inflammatory and antifibrotic properties. We evaluated the role of Pin 1 in renal fibrogenesis by eva...

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Detalles Bibliográficos
Autores principales: Reese, Shannon, Vidyasagar, Aparna, Jacobson, Lynn, Acun, Zeki, Esnault, Stephane, Hullett, Debra, Malter, James S, Djamali, Arjang
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823698/
https://www.ncbi.nlm.nih.gov/pubmed/20047646
http://dx.doi.org/10.1186/1755-1536-3-1

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