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Wnt-5a occludes Aβ oligomer-induced depression of glutamatergic transmission in hippocampal neurons

BACKGROUND: Soluble amyloid-β (Aβ;) oligomers have been recognized to be early and key intermediates in Alzheimer's disease (AD)-related synaptic dysfunction. Aβ oligomers block hippocampal long-term potentiation (LTP) and impair rodent spatial memory. Wnt signaling plays an important role in n...

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Detalles Bibliográficos
Autores principales:	Cerpa, Waldo, Farías, Ginny G, Godoy, Juan A, Fuenzalida, Marco, Bonansco, Christian, Inestrosa, Nibaldo C
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823745/ https://www.ncbi.nlm.nih.gov/pubmed/20205789 http://dx.doi.org/10.1186/1750-1326-5-3

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