Immunoproteasome LMP2 60HH Variant Alters MBP Epitope Generation and Reduces the Risk to Develop Multiple Sclerosis in Italian Female Population

BACKGROUND: Albeit several studies pointed out the pivotal role that CD4+T cells have in Multiple Sclerosis, the CD8+ T cells involvement in the pathology is still in its early phases of investigation. Proteasome degradation is the key step in the production of MHC class I-restricted epitopes and th...

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Detalles Bibliográficos
Autores principales: Mishto, Michele, Bellavista, Elena, Ligorio, Claudia, Textoris-Taube, Kathrin, Santoro, Aurelia, Giordano, Mara, D'Alfonso, Sandra, Listì, Florinda, Nacmias, Benedetta, Cellini, Elena, Leone, Maurizio, Grimaldi, Luigi M.E., Fenoglio, Chiara, Esposito, Federica, Martinelli-Boneschi, Filippo, Galimberti, Daniela, Scarpini, Elio, Seifert, Ulrike, Amato, Maria Pia, Caruso, Calogero, Foschini, Maria P., Kloetzel, Peter M., Franceschi, Claudio
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823778/
https://www.ncbi.nlm.nih.gov/pubmed/20174631
http://dx.doi.org/10.1371/journal.pone.0009287

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