The X-Ray Crystal Structure of Escherichia coli Succinic Semialdehyde Dehydrogenase; Structural Insights into NADP(+)/Enzyme Interactions

BACKGROUND: In mammals succinic semialdehyde dehydrogenase (SSADH) plays an essential role in the metabolism of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) to succinic acid (SA). Deficiency of SSADH in humans results in elevated levels of GABA and γ-Hydroxybutyric acid (GHB), which le...

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Detalles Bibliográficos
Autores principales: Langendorf, Christopher G., Key, Trevor L. G., Fenalti, Gustavo, Kan, Wan-Ting, Buckle, Ashley M., Caradoc-Davies, Tom, Tuck, Kellie L., Law, Ruby H. P., Whisstock, James C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823781/
https://www.ncbi.nlm.nih.gov/pubmed/20174634
http://dx.doi.org/10.1371/journal.pone.0009280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823781/
https://www.ncbi.nlm.nih.gov/pubmed/20174634
http://dx.doi.org/10.1371/journal.pone.0009280

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