Fenretinide induces mitochondrial ROS and inhibits the mitochondrial respiratory chain in neuroblastoma

Fenretinide induces apoptosis in neuroblastoma by induction of reactive oxygen species (ROS). In this study, we investigated the role of mitochondria in fenretinide-induced cytotoxicity and ROS production in six neuroblastoma cell lines. ROS induction by fenretinide was of mitochondrial origin, demo...

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Detalles Bibliográficos
Autores principales: Cuperus, Roos, Leen, René, Tytgat, Godelieve A. M., Caron, Huib N., van Kuilenburg, André B. P.
Formato: Texto
Lenguaje:English
Publicado: SP Birkhäuser Verlag Basel 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824117/
https://www.ncbi.nlm.nih.gov/pubmed/19941060
http://dx.doi.org/10.1007/s00018-009-0212-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824117/
https://www.ncbi.nlm.nih.gov/pubmed/19941060
http://dx.doi.org/10.1007/s00018-009-0212-2

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