A side effect resource to capture phenotypic effects of drugs

The molecular understanding of phenotypes caused by drugs in humans is essential for elucidating mechanisms of action and for developing personalized medicines. Side effects of drugs (also known as adverse drug reactions) are an important source of human phenotypic information, but so far research o...

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Autores principales: Kuhn, Michael, Campillos, Monica, Letunic, Ivica, Jensen, Lars Juhl, Bork, Peer
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824526/
https://www.ncbi.nlm.nih.gov/pubmed/20087340
http://dx.doi.org/10.1038/msb.2009.98
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author Kuhn, Michael
Campillos, Monica
Letunic, Ivica
Jensen, Lars Juhl
Bork, Peer
author_facet Kuhn, Michael
Campillos, Monica
Letunic, Ivica
Jensen, Lars Juhl
Bork, Peer
author_sort Kuhn, Michael
collection PubMed
description The molecular understanding of phenotypes caused by drugs in humans is essential for elucidating mechanisms of action and for developing personalized medicines. Side effects of drugs (also known as adverse drug reactions) are an important source of human phenotypic information, but so far research on this topic has been hampered by insufficient accessibility of data. Consequently, we have developed a public, computer-readable side effect resource (SIDER) that connects 888 drugs to 1450 side effect terms. It contains information on frequency in patients for one-third of the drug–side effect pairs. For 199 drugs, the side effect frequency of placebo administration could also be extracted. We illustrate the potential of SIDER with a number of analyses. The resource is freely available for academic research at http://sideeffects.embl.de.
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spelling pubmed-28245262010-02-18 A side effect resource to capture phenotypic effects of drugs Kuhn, Michael Campillos, Monica Letunic, Ivica Jensen, Lars Juhl Bork, Peer Mol Syst Biol Report The molecular understanding of phenotypes caused by drugs in humans is essential for elucidating mechanisms of action and for developing personalized medicines. Side effects of drugs (also known as adverse drug reactions) are an important source of human phenotypic information, but so far research on this topic has been hampered by insufficient accessibility of data. Consequently, we have developed a public, computer-readable side effect resource (SIDER) that connects 888 drugs to 1450 side effect terms. It contains information on frequency in patients for one-third of the drug–side effect pairs. For 199 drugs, the side effect frequency of placebo administration could also be extracted. We illustrate the potential of SIDER with a number of analyses. The resource is freely available for academic research at http://sideeffects.embl.de. Nature Publishing Group 2010-01-19 /pmc/articles/PMC2824526/ /pubmed/20087340 http://dx.doi.org/10.1038/msb.2009.98 Text en Copyright © 2010, EMBO and Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution and reproduction in any medium, provided the original author and source are credited. Creation of derivative works is permitted but the resulting work may be distributed only under the same or similar licence to this one. This licence does not permit commercial exploitation without specific permission.
spellingShingle Report
Kuhn, Michael
Campillos, Monica
Letunic, Ivica
Jensen, Lars Juhl
Bork, Peer
A side effect resource to capture phenotypic effects of drugs
title A side effect resource to capture phenotypic effects of drugs
title_full A side effect resource to capture phenotypic effects of drugs
title_fullStr A side effect resource to capture phenotypic effects of drugs
title_full_unstemmed A side effect resource to capture phenotypic effects of drugs
title_short A side effect resource to capture phenotypic effects of drugs
title_sort side effect resource to capture phenotypic effects of drugs
topic Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824526/
https://www.ncbi.nlm.nih.gov/pubmed/20087340
http://dx.doi.org/10.1038/msb.2009.98
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