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Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of Geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis

BACKGROUND: Geranylgeranyltransferase I (GGTase I) has emerged as a cancer therapeutic target. Accordingly, small molecules that inhibit GGTase I have been developed and exhibit encouraging anticancer activity in preclinical studies. However, their underlying anticancer mechanisms remain unclear. He...

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Detalles Bibliográficos
Autores principales:	Chen, Shuzhen, Fu, Lei, Raja, Shruti M, Yue, Ping, Khuri, Fadlo R, Sun, Shi-Yong
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824632/ https://www.ncbi.nlm.nih.gov/pubmed/20113484 http://dx.doi.org/10.1186/1476-4598-9-23

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