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Exhaled and nasal nitric oxide in laryngectomized patients

BACKGROUND: Nitric oxide (NO) shows differing concentrations in lower and upper airways. Patients after total laryngectomy are the only individuals, in whom a complete separation of upper and lower airways is guaranteed. Thus the objective of our study was to assess exhaled and nasal NO in these pat...

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Autores principales: Kramer, Matthias F, Olzowy, Bernhard, Bihler, Annette, de la Motte, Dorothea, Nowak, Dennis, Jörres, Rudolf A, Dressel, Holger
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824635/
https://www.ncbi.nlm.nih.gov/pubmed/20105339
http://dx.doi.org/10.1186/1471-2466-10-4
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author Kramer, Matthias F
Olzowy, Bernhard
Bihler, Annette
de la Motte, Dorothea
Nowak, Dennis
Jörres, Rudolf A
Dressel, Holger
author_facet Kramer, Matthias F
Olzowy, Bernhard
Bihler, Annette
de la Motte, Dorothea
Nowak, Dennis
Jörres, Rudolf A
Dressel, Holger
author_sort Kramer, Matthias F
collection PubMed
description BACKGROUND: Nitric oxide (NO) shows differing concentrations in lower and upper airways. Patients after total laryngectomy are the only individuals, in whom a complete separation of upper and lower airways is guaranteed. Thus the objective of our study was to assess exhaled and nasal NO in these patients. METHODS: Exhaled bronchial NO (FE(NO)) and nasal nitric oxide (nNO) were measured in patients after total laryngectomy (n = 14) and healthy controls (n = 24). To assess lung function we additionally performed spirometry. Co-factors possibly influencing NO, such as smoking, infections, and atopy were excluded. RESULTS: There was a markedly (p < 0.001) lower FE(NO )in patients after total laryngectomy (median (range): 4 (1-22) ppb) compared to healthy controls 21 (9-41) ppb). In contrast, nNO was comparable between groups (1368 versus 1380 in controls) but showed higher variability in subjects after laryngectomy. CONCLUSIONS: Our data suggest that either bronchial NO production in patients who underwent laryngectomy is very low, possibly due to alterations of the mucosa or oxidant production/inflammation, or that substantial contributions to FE(NO )arise from the larynx, pharynx and mouth, raising FE(NO )despite velum closure. The data fit to those indicating a substantial contribution to FE(NO )by the mouth in healthy subjects. The broader range of nNO values found in subjects after laryngectomy may indicate chronic alteration or oligo-symptomatic inflammation of nasal mucosa, as frequently found after total laryngectomy.
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spelling pubmed-28246352010-02-19 Exhaled and nasal nitric oxide in laryngectomized patients Kramer, Matthias F Olzowy, Bernhard Bihler, Annette de la Motte, Dorothea Nowak, Dennis Jörres, Rudolf A Dressel, Holger BMC Pulm Med Research article BACKGROUND: Nitric oxide (NO) shows differing concentrations in lower and upper airways. Patients after total laryngectomy are the only individuals, in whom a complete separation of upper and lower airways is guaranteed. Thus the objective of our study was to assess exhaled and nasal NO in these patients. METHODS: Exhaled bronchial NO (FE(NO)) and nasal nitric oxide (nNO) were measured in patients after total laryngectomy (n = 14) and healthy controls (n = 24). To assess lung function we additionally performed spirometry. Co-factors possibly influencing NO, such as smoking, infections, and atopy were excluded. RESULTS: There was a markedly (p < 0.001) lower FE(NO )in patients after total laryngectomy (median (range): 4 (1-22) ppb) compared to healthy controls 21 (9-41) ppb). In contrast, nNO was comparable between groups (1368 versus 1380 in controls) but showed higher variability in subjects after laryngectomy. CONCLUSIONS: Our data suggest that either bronchial NO production in patients who underwent laryngectomy is very low, possibly due to alterations of the mucosa or oxidant production/inflammation, or that substantial contributions to FE(NO )arise from the larynx, pharynx and mouth, raising FE(NO )despite velum closure. The data fit to those indicating a substantial contribution to FE(NO )by the mouth in healthy subjects. The broader range of nNO values found in subjects after laryngectomy may indicate chronic alteration or oligo-symptomatic inflammation of nasal mucosa, as frequently found after total laryngectomy. BioMed Central 2010-01-28 /pmc/articles/PMC2824635/ /pubmed/20105339 http://dx.doi.org/10.1186/1471-2466-10-4 Text en Copyright ©2010 Kramer et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research article
Kramer, Matthias F
Olzowy, Bernhard
Bihler, Annette
de la Motte, Dorothea
Nowak, Dennis
Jörres, Rudolf A
Dressel, Holger
Exhaled and nasal nitric oxide in laryngectomized patients
title Exhaled and nasal nitric oxide in laryngectomized patients
title_full Exhaled and nasal nitric oxide in laryngectomized patients
title_fullStr Exhaled and nasal nitric oxide in laryngectomized patients
title_full_unstemmed Exhaled and nasal nitric oxide in laryngectomized patients
title_short Exhaled and nasal nitric oxide in laryngectomized patients
title_sort exhaled and nasal nitric oxide in laryngectomized patients
topic Research article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824635/
https://www.ncbi.nlm.nih.gov/pubmed/20105339
http://dx.doi.org/10.1186/1471-2466-10-4
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