CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis

Active vaccination can be effective as a post-exposure prophylaxis, but the rapidity of the immune response induced, relative to the incubation time of the pathogen, is critical. We show here that CD40mAb conjugated to antigen induces a more rapid specific antibody response than currently used immun...

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Detalles Bibliográficos
Autores principales: Bhagawati-Prasad, Vijay NS, De Leenheer, Evy, Keefe, Nadine P, Ryan, Lorna A, Carlring, Jennifer, Heath, Andrew W
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824643/
https://www.ncbi.nlm.nih.gov/pubmed/20205811
http://dx.doi.org/10.1186/1476-8518-8-1
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author Bhagawati-Prasad, Vijay NS
De Leenheer, Evy
Keefe, Nadine P
Ryan, Lorna A
Carlring, Jennifer
Heath, Andrew W
author_facet Bhagawati-Prasad, Vijay NS
De Leenheer, Evy
Keefe, Nadine P
Ryan, Lorna A
Carlring, Jennifer
Heath, Andrew W
author_sort Bhagawati-Prasad, Vijay NS
collection PubMed
description Active vaccination can be effective as a post-exposure prophylaxis, but the rapidity of the immune response induced, relative to the incubation time of the pathogen, is critical. We show here that CD40mAb conjugated to antigen induces a more rapid specific antibody response than currently used immunological adjuvants, alum and monophosphoryl lipid A™.
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spelling pubmed-28246432010-02-19 CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis Bhagawati-Prasad, Vijay NS De Leenheer, Evy Keefe, Nadine P Ryan, Lorna A Carlring, Jennifer Heath, Andrew W J Immune Based Ther Vaccines Short Report Active vaccination can be effective as a post-exposure prophylaxis, but the rapidity of the immune response induced, relative to the incubation time of the pathogen, is critical. We show here that CD40mAb conjugated to antigen induces a more rapid specific antibody response than currently used immunological adjuvants, alum and monophosphoryl lipid A™. BioMed Central 2010-02-04 /pmc/articles/PMC2824643/ /pubmed/20205811 http://dx.doi.org/10.1186/1476-8518-8-1 Text en Copyright ©2010 Bhagawati-Prasad et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Bhagawati-Prasad, Vijay NS
De Leenheer, Evy
Keefe, Nadine P
Ryan, Lorna A
Carlring, Jennifer
Heath, Andrew W
CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis
title CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis
title_full CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis
title_fullStr CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis
title_full_unstemmed CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis
title_short CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis
title_sort cd40mab adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824643/
https://www.ncbi.nlm.nih.gov/pubmed/20205811
http://dx.doi.org/10.1186/1476-8518-8-1
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