Neutrophil elastase downmodulates native G-CSFR expression and granulocyte-macrophage colony formation

BACKGROUND: The granulocyte colony-stimulating factor receptor (G-CSFR) plays a critical role in maintaining homeostatic levels of circulating neutrophils (PMN). The mechanisms modulating G-CSFR surface expression to prevent chronic neutrophilia are poorly understood. Here, we report that neutrophil...

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Detalles Bibliográficos
Autores principales: Piper, Melissa G, Massullo, Pam R, Loveland, Megan, Druhan, Lawrence J, Kindwall-Keller, Tamila L, Ai, Jing, Copelan, Alexander, Avalos, Belinda R
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824667/
https://www.ncbi.nlm.nih.gov/pubmed/20205821
http://dx.doi.org/10.1186/1476-9255-7-5

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