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Abdominal muscle fatigue following exercise in chronic obstructive pulmonary disease

BACKGROUND: In patients with chronic obstructive pulmonary disease, a restriction on maximum ventilatory capacity contributes to exercise limitation. It has been demonstrated that the diaphragm in COPD is relatively protected from fatigue during exercise. Because of expiratory flow limitation the ab...

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Autores principales: Hopkinson, Nicholas S, Dayer, Mark J, Moxham, John, Polkey, Michael I
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824704/
https://www.ncbi.nlm.nih.gov/pubmed/20132549
http://dx.doi.org/10.1186/1465-9921-11-15
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author Hopkinson, Nicholas S
Dayer, Mark J
Moxham, John
Polkey, Michael I
author_facet Hopkinson, Nicholas S
Dayer, Mark J
Moxham, John
Polkey, Michael I
author_sort Hopkinson, Nicholas S
collection PubMed
description BACKGROUND: In patients with chronic obstructive pulmonary disease, a restriction on maximum ventilatory capacity contributes to exercise limitation. It has been demonstrated that the diaphragm in COPD is relatively protected from fatigue during exercise. Because of expiratory flow limitation the abdominal muscles are activated early during exercise in COPD. This adds significantly to the work of breathing and may therefore contribute to exercise limitation. In healthy subjects, prior expiratory muscle fatigue has been shown itself to contribute to the development of quadriceps fatigue. It is not known whether fatigue of the abdominal muscles occurs during exercise in COPD. METHODS: Twitch gastric pressure (TwT10Pga), elicited by magnetic stimulation over the 10(th )thoracic vertebra and twitch transdiaphragmatic pressure (TwPdi), elicited by bilateral anterolateral magnetic phrenic nerve stimulation were measured before and after symptom-limited, incremental cycle ergometry in patients with COPD. RESULTS: Twenty-three COPD patients, with a mean (SD) FEV(1 )40.8(23.1)% predicted, achieved a mean peak workload of 53.5(15.9) W. Following exercise, TwT(10)Pga fell from 51.3(27.1) cmH(2)O to 47.4(25.2) cmH(2)O (p = 0.011). TwPdi did not change significantly; pre 17.0(6.4) cmH(2)O post 17.5(5.9) cmH(2)O (p = 0.7). Fatiguers, defined as having a fall TwT10Pga ≥ 10% had significantly worse lung gas transfer, but did not differ in other exercise parameters. CONCLUSIONS: In patients with COPD, abdominal muscle but not diaphragm fatigue develops following symptom limited incremental cycle ergometry. Further work is needed to establish whether abdominal muscle fatigue is relevant to exercise limitation in COPD, perhaps indirectly through an effect on quadriceps fatigability.
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spelling pubmed-28247042010-02-20 Abdominal muscle fatigue following exercise in chronic obstructive pulmonary disease Hopkinson, Nicholas S Dayer, Mark J Moxham, John Polkey, Michael I Respir Res Research BACKGROUND: In patients with chronic obstructive pulmonary disease, a restriction on maximum ventilatory capacity contributes to exercise limitation. It has been demonstrated that the diaphragm in COPD is relatively protected from fatigue during exercise. Because of expiratory flow limitation the abdominal muscles are activated early during exercise in COPD. This adds significantly to the work of breathing and may therefore contribute to exercise limitation. In healthy subjects, prior expiratory muscle fatigue has been shown itself to contribute to the development of quadriceps fatigue. It is not known whether fatigue of the abdominal muscles occurs during exercise in COPD. METHODS: Twitch gastric pressure (TwT10Pga), elicited by magnetic stimulation over the 10(th )thoracic vertebra and twitch transdiaphragmatic pressure (TwPdi), elicited by bilateral anterolateral magnetic phrenic nerve stimulation were measured before and after symptom-limited, incremental cycle ergometry in patients with COPD. RESULTS: Twenty-three COPD patients, with a mean (SD) FEV(1 )40.8(23.1)% predicted, achieved a mean peak workload of 53.5(15.9) W. Following exercise, TwT(10)Pga fell from 51.3(27.1) cmH(2)O to 47.4(25.2) cmH(2)O (p = 0.011). TwPdi did not change significantly; pre 17.0(6.4) cmH(2)O post 17.5(5.9) cmH(2)O (p = 0.7). Fatiguers, defined as having a fall TwT10Pga ≥ 10% had significantly worse lung gas transfer, but did not differ in other exercise parameters. CONCLUSIONS: In patients with COPD, abdominal muscle but not diaphragm fatigue develops following symptom limited incremental cycle ergometry. Further work is needed to establish whether abdominal muscle fatigue is relevant to exercise limitation in COPD, perhaps indirectly through an effect on quadriceps fatigability. BioMed Central 2010 2010-02-04 /pmc/articles/PMC2824704/ /pubmed/20132549 http://dx.doi.org/10.1186/1465-9921-11-15 Text en Copyright ©2010 Hopkinson et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Hopkinson, Nicholas S
Dayer, Mark J
Moxham, John
Polkey, Michael I
Abdominal muscle fatigue following exercise in chronic obstructive pulmonary disease
title Abdominal muscle fatigue following exercise in chronic obstructive pulmonary disease
title_full Abdominal muscle fatigue following exercise in chronic obstructive pulmonary disease
title_fullStr Abdominal muscle fatigue following exercise in chronic obstructive pulmonary disease
title_full_unstemmed Abdominal muscle fatigue following exercise in chronic obstructive pulmonary disease
title_short Abdominal muscle fatigue following exercise in chronic obstructive pulmonary disease
title_sort abdominal muscle fatigue following exercise in chronic obstructive pulmonary disease
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824704/
https://www.ncbi.nlm.nih.gov/pubmed/20132549
http://dx.doi.org/10.1186/1465-9921-11-15
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